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Finally, AC regulates macrophage polarization (favoring M2 over pro-inflammatory M1 phenotype), which can promote tissue repair and resolution of inflammation (Ren et al

[25] Murine cells overexpressing the NADase CD38 consumed less oxygen, had higher lactate levels, and had abnormal mitochondria, including traits like missing or enlarged cristae, which lends more proof of NAD+s role in promoting mitochondrial and metabolic health

Biochim Biophys Acta 2010, 1802: 396405

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