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By damaging IL-17 cytokines, AIRE gene mutations are thought to impair the IL-17 pathway's function, resulting in CMC in people with APECED
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In obesity, hypertrophic expansion of adipocytes leads to hypoxia, oxidative stress, and the release of pro-inflammatory adipokines, thereby promoting insulin resistance and ectopic lipid deposition [31]
2C), Table 2 and Fig
The overall certainty of the evidence was moderate
doi: 10.1586/14789450.5.2.157
