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In 1947, Leon M Meyer described the results of his study on a small number of pernicious anemia patients with positive hematological responses resulting from the intake of very high doses of folic acid (2050 mg/d) (10)

Another study by Pickart et al

Hypothalamic and thyroidal regulation of growth hormone in tilapia

High-dose protocols (1.52mg daily) push toward the upper threshold where copper ion accumulation becomes a concern

All cell counts were divided by dentate gyrus area sampled to yield a density of cells