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Investigating silibinin anti-cancer effects through drug delivery system The low water solubility and poor bioavailability of silibinin limit its therapeutic efficacy at tumor sites

Among them, the amount of Cys is usually the least in cells, so it is considered to be the key factor limiting the de novo synthesis of GSH

Redox homeostasis disruption is responsible for synaptic dysfunction, neuroinflammation, and disrupted neuronal signaling, worsening the fundamental symptoms of ASD

Conversely, Cai et al

That being said, its important to keep in mind that the 4Rs is a general framework - this process needs to be personalized for each individual for the most targeted, effective, and well tolerated approach