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10.1016/j.imlet.2014.05.008 126

[13] Orally ingested compounds first pass through the gastrointestinal tract and gut microbiome where some xenobiotics can be metabolized before entering the bloodstream, while inhaled, intravenous, or dermal exposures enter circulation more directly

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Mechanism 4: Anti-inflammatory via melanocortin pathway KLOW only

Bazopoulou D, Knoefler D, Zheng Y, Ulrich K, Oleson BJ, Xie L, et al

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