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Also, circulating IGF-I deficiency due to hepatic under-insulinization in type 1 diabetes is associated with low GHBP levels
J., Nieman, L
This makes the disease more difficult to treat (23)
Helps in DNA synthesis and repair
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379 The stress-induced mt-ISR, triggered by OPA1 loss, also contributes to muscle loss, and the reduction of FGF21 (a downstream hormone of mt-ISR) can mitigate this muscle wasting
