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Indeed, studies using in vitro models, as well as tissues from rodent models of and humans with obesity and type 2 diabetes, have revealed a network of altered miRNAs targeting the insulin receptor, as well as the IRS/PI3K/Akt pathways, thus, contributing to metabolic abnormalities [110]

Thinking outside the bug: a unique assay to measure intracellular drug penetration in gram-negative bacteria

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10.1001/jama.2008.600 186

[DOI] [PMC free article] [PubMed] [Google Scholar] 89.Ponnusamy, K., Ramasamy, M., Savarimuthu, I

We found a significant TRPM3-calcium pathway dysfunction in ME/CFS, resulting in impaired calcium entry into mitochondria, a region of the cell responsible for energy production, she said