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flavus were summarized in Table 3, with 90% level of confidence, F-value 2.82 and p -value 0.04, revealing the goodness of regression model and significance of the designed model

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At the molecular level, chronic administration of TCAs leads to the desensitization of 1-adrenergic and 5-HT2 serotonergic receptorsan adaptive phenomenon thought to underlie the development of sustained antidepressant effects over time ( Selective serotonin reuptake inhibitors (SSRIs) are currently the most prescribed antidepressants due to their favorable efficacy and safety profiles

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