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Why this matters: Growth hormone secretion is highest during deep sleep REM cycles improve memory, cognition, and nervous system repair Better sleep = better recovery, muscle growth, insulin sensitivity, and mood MK-677 administration significantly improved REM sleep duration and quality in both younger and older subjects, with corresponding increases in nighttime GH secretion. Van Cauter et al., Sleep 5

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PLGA segments prevented the initial burst release of NO as protecting layer and it had the important role for NO-releasing behavior of NPs

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