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Other studies reported that TMAO increased the expression of CD36 and the formation of foam cells induced by ox-LDL, which could be reduced by siRNA-mediated knockdown of CD36 as well as inhibitors of MAPK (SB230580) and JNK (SP600125)

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They enhance myocardial contractility by inhibiting the activity of the sodiumpotassium pump (Na + /K + -ATPase), which increases intracellular calcium ion concentrations, making them important drugs for the treatment of cardiovascular diseases

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