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In the Phase III NefIgArd trial, patients treated with Tarpeyo saw significantly better kidney function, as measured by the estimated glomerular filtration rate (eGFR) versus placebo after nine months on the drug and 15 months of follow-up

Through its interaction with NOTCH1, CHAC1/BOTCH inhibits NOTCH1 activity and thereby prevents neuronal stem cell self-renewal (Scheckhuber et al., 2007)

doi:10.1080/10715760801998638

doi: 10.1242/bio.20134259 98 KatiyarSSBriedisAVPorterJW
Nutrition Research, 17 (3), 463473

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