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TMAO may be a key mediator in the cross-talk between endocrine cells and exocrine cells in the pancreas

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The feature (metabolite or ratio) with the highest area under the curve in the ROC curve analysis was 3,4-hydroxyphenyl lactate/creatine (Figure 2C), with an AUC of 0.88, and a jointly maximized sensitivity and specificity of 0.8/0.8

Nonderivatized samples were prepared, with isotope or stable isotope-labeled analytes serving as internal standards

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