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B12 is a cofactor for the enzyme, methylmalonyl-CoA mutase, which transforms methylmalonyl-CoA into succinyl-CoA, which the body can directly use in the Krebs cycle to produce ATP

doi: 10.1038/nrdp.2017.40, 2

doi: 10.1016/s0165-6147(00)01664-3

Diagnosis and Assessment Supplementation Options for Vitamin B12 Deficiency Who Requires Methylcobalamin Injection

Tests for TGN levels determine the thioguanine count in DNA structure and should ideally be requested at weeks 4 and 12 after starting therapy, thereafter bi-annually/annually, or 4 weeks after a dose change[42]

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