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Metformin-induced vitamin B12 deficiency can cause or worsen distal symmetrical, autonomic and cardiac neuropathy in the patient with diabetes

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DAG-mediated activation of protein kinase C theta (PKC ) leads to phosphorylation of IRS residue S307
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Antibody action on cell targets is mediated by FcRs, which then activate CDC, ADCC, ADCP, and direct signaling
