glutathione conjugate of ethacrynic acid Potent anti-proliferative actions a non-diuretic glucosamine derivative of Glutathione-Mediated Conjugation of Anticancer Drugs:

Rotate sites to reduce irritation

, Morgan, R

Catalytic therapy of cancer by ascorbic acid involves redox cycling of exogenous/endogenous copper ions and generation of reactive oxygen species

However, most Fenton-active metals do not preferably bind the thiolate group of glutathione and of proteins, but rather other nitrogen- and oxygen-containing functional groups, such as the imidazole nitrogen of histidine and the deprotonated alkoxy function of serine and threonine

Glutathione is not a one-time fix ongoing use is typically required to maintain benefits

J Biol Chem 246: 70957105, 1971 [PubMed] [Google Scholar] 55.Van Der Werf P, Griffith OW, Meister A: 5-Oxo-L-prolinase (L-pyroglutamate hydrolase)