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J Clin Endocrinol Metab (2017) 102(10):383947

This demonstrates that DHEA caused a systemic inflammatory response and activated local ovarian signaling pathways in the ovaries

10.1016/0014-5793(95)01050-O

Transgenerational epigenetic effects have also been induced in germ cells, mostly through DNA methylation and epimutations

This is why, at the beginning of the 20th century, when it was discovered that eating liver improved patients with pernicious anemia, they had to eat huge amounts to achieve a pharmacological effect. In these cases, we find an approximate absorption of, with luck, between 1-2% of the dose administered, but it is not uncommon for it to be even lower (0.5%) depending on the size of the dose, previous reserves, and other factors and individual conditions of each subject