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Description
In the periplasmic leaflet, enzymes can modify the phosphate moieties in the 1- and 4-positions of the disaccharide backbone by hydrolysis or by the addition of cationic sugars or phosphoethanolamine to prevent binding to host defence molecules so influencing the virulence of some pathogens and their resistance to antibiotics

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Byrd-Bredbenner C, Moe G, Beshgetoor D, Berning J

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doi: 10.3389/fimmu.2021.826067 186 BenvengaSLakshmananMTrimarchiF

Phase 1 and phase 2a, first-in-human (FIH) study, of DRP-104, a broad glutamine antagonist, in adult patients with advanced solid tumors
