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It has been used extensively in preclinical models of cancer and, with increasing frequency, in patients with cancer

Pectolinarigenin has been reported to inhibit colon cancer cells in both in vivo and in vitro models ( Transcriptomic and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses suggested that the PPAR/GPX4 signaling pathway plays a critical role in the protective effect of pectolinarigenin against 5-FU-induced intestinal epithelial cell injury

[DOI] [PubMed] [Google Scholar] 63.Lozic M., Stambolija V., Krezic I., Dugandzic A., Zivanovic-Posilovic G., Gojkovic S., Kovacevic J., Vrdoljak L., Mirkovic I., Kokot A., et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 196.Ross JL

Reprogramming of TAMs via the STAT3/CD47-SIRP axis promotes acquired resistance to EGFR-TKIs in lung cancer