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Natural materials, including silk fibroin (Zeng et al., 2014), fibrin (Buser et al., 2011), collagen (Huang et al., 2010), ECM (Borem et al., 2017), Gelatin (Daly et al., 2018

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Vasiliou et al., 1995)

Signs include: Swelling in the face or lips Trouble breathing Skin rash spreading quickly 4

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Patients should understand that such treatments are not substitutes for evidence-based weight management strategies endorsed by NICE, including dietary modification, physical activity, andwhere appropriatelicensed pharmacotherapy
