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However, because OSC reactivity can lead to off-target thiol modification, clinical development requires careful concentrationresponse optimization and, for less stable compounds such as allicin analogues, formulation or localized delivery strategies

Sharma R, Kim SY, Sharma A, Zhang Z, Kambhampati SP, Kannan S, et al

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It also diminished induction of TNF- and IL-6, decreased NF-B nuclear translocation and p38 mitogen activated protein kinase phosphorylation, abolished intracellular hydrogen peroxide production, restored intracellular thiol levels, and reduced virus titre