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The depletion of GSH potentiates CYP2E1-mediated oxidative stress and injury in liver cells
The enzyme activity was expressed as nmoles of -ketobutyrate, which formed during a one-minute-incubation at 37 C per 1 mg of protein
Another study further demonstrated that autophagy-related ferroptosis induced by GSH reduction (45)
doi:10.1016/j.abb.2006.01.013 Ding Y, Choi KJ, Kim JH, Han X, Piao Y, Jeong JH, Choe W, Kang I, Ha J, Forman HJ, Lee J, Yoon KS, Kim SS (2008) Endogenous hydrogen peroxide regulates glutathione redox via nuclear factor erythroid 2-related factor 2 downstream of phosphatidylinositol 3-kinase during muscle differentiation
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