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However, some rare side effects of too much vitamin B12 can include: Headache Weakness Nausea Diarrhea Tingling sensations in the hands and feet Allergic reactions or skin rash (uncommon) When To Seek Medical Advice Risk of vitamin B12 deficiency: Groups at a higher risk of vitamin B12 deficiency include older adults, people who only eat plant-based foods (vegans and vegetarians), and those with certain chronic conditions (gastrointestinal disorders that can affect vitamin absorption)

FDA-approved GLP-1 peptides such as semaglutide and tirzepatide have the strongest safety data, with GoodRx confirming these prescription-only medications are safe and effective when used as directed, a status consistent with the FDA's approval of tirzepatide for chronic weight management

Standard treatments like semaglutide and tirzepatide deliver substantial clinical outcomes for the majority of patients

One such combination therapy is currently being evaluated in clinical trials and is discussed later in this article

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