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Description
By degrading GSH, CHAC1 perturbs redox homeostasis and can effectively blunt the NRF2-driven cytoprotective response
Inhibition of system x c by erastin and the clinically approved anticancer drug sorafenib triggers some aspects of ER stress as well as ferroptosis, indicating a possible link between ER stress and ferroptosis [40]
[DOI] [PubMed] [Google Scholar] 44.Lurie R, Ben-Amitai D, Laron Z
CircRNAs, a distinct class of ncRNAs, form covalently closed loops without 5 caps and 3 poly(A) tails
Through a systematic and comprehensive analysis of the multi-dimensional functions, heterogeneous regulation and roles in therapeutic resistance of the SSP across cancer types, this review aims to elucidate the conserved principles and cancer-specific characteristics of the SSP as a metabolic hub
The authors thank J
