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Moreover, diverse extracellular molecular signals, including neurotransmitters, neurotrophins, extracellular matrix proteins, contact-mediated ligands, and secreted diffusible cues, shape neural circuit development and modulate brain connectivity during early life ( There is increasing recognition that imbalances in the gut microbial community, referred to as dysbiosis, are associated with a range of neurological disorders

however, the prolonged inhibition of a single pathway may lead to compensatory enhancement of other pathways

1112) in one (Bucher et al., 1986