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The nasal route allows transmucosal absorption and bypasses hepatic first-pass metabolism, though comparative bioavailability data relative to subcutaneous administration remain limited

Additional information Competing interests The vitamin/mineral formulation designed for this study by JBA and TA has since been improved and made available as an over-the-counter product, Syndion, by Yasoo Health, but none of the authors receive any royalties from the sale of Syndion or any Yasoo Health products
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Chronic alcohol consumption also constitutes a well-documented cause of permeability that must be addressed in any comprehensive concussion therapy program

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