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While lipo B12 injections are very safe for most people, its best to consult a doctor before starting injections, especially if you: Have a personal or family history of autoimmune disorders Have methylmalonic acidemia or other B12-related genetic disorders Are you pregnant or breastfeeding Have kidney disease or liver disease Have leukaemia or other blood disorders Have had allergic reactions to B12 supplements before In these cases, your doctor can determine if injections are suitable or an alternative treatment is better

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For instance, the effectiveness of precursor administration on NAD + levels could be improved by PNP inhibition 25

10.1039/d1gc00503k 22 BrownM

for major depressive disorder, its clinical story is mixed: the Phase II trials primary depression endpoint was not met