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Cell 157 (1), 121141

These findings emphasize the need for metabolome-resolved clinical trials, where CRISPR-edited organoids model patient-specific mutations in ACMSD to enhance NAD + salvage, while spatial lipidomics can track the dissemination of arachidonic acid cascades from peri-infarct neurons to distant renal tubules

Serum CK was selected as one of our primary measures of muscle damage and fatigue

sometimes used synonymously with heart failure Cardiac insufficiency - sometimes used synonymously with heart failure Heart failure - the heart's inability to pump enough blood for all of the body's needs Ischemia - inadequate blood supply to an organ or part of the body Observational study - a human research study in which no experimental intervention or treatment is applied, and participants are simply observed over time Oxidative stress - a situation in which the production of reactive oxygen species exceeds the ability of an organism to eliminate or neutralize them Placebo - a chemically inactive substance Randomized controlled trial - a human research study in which participants are assigned by chance alone to receive either an experimental agent (the treatment group) or a placebo (the control group) Reactive oxygen species (ROS) - highly unstable oxygen-containing compounds that react easily with nearby cellular structures, potentially causing damage Authors and Reviewers Originally written in May 2015 by: Giana Angelo, Ph.D

In aged astrocytes, lipolytic defects (e.g., reduced adipose-triglyceride lipase activity) exacerbate lipid droplet accumulation, converting protective storage into neurotoxic reservoirs