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GSH levels, turnover rates and/or oxidation state can be compromised by inherited or aquired defects in the enzymes, transporters, signaling molecules, or transcription factors that are involved in its homeostasis, or from exposure to reactive chemicals or metabolic intermediates

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Many enzymes are redox sensitive and easily oxidized, rendering them inactive even though protein expression level is high

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FIGURE 31-3: Metabolism of the catecholamine neurotransmitters

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