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Acknowledgments The authors thank PurMed Global (Delray Beach, Florida) for donating cannabidiol and ANATOMED Laboratory (Bauru, Brazil) for their anatomopathological analysis at no cost

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One of the most promising ACT inhibitors was found 8-aza-7-deazapurine analogue of PMEA in the form of bis(isopropyl phenylalanine) amidate with IC 50 value16 nM and substantial selectivity over mammalian adenylate cyclases (esnek et al., 2018)
