cjc-1295 ipamorelin info (Mod GRF 1-29) & & GHRP-2 - 9MG CJC 1295, Ipamorelin and Retatrutide:

Elevated intracellular Ca 2+ levels trigger downstream neurotoxic cascades, including activation of proteases (e.g., calpains), generation of reactive oxygen species (ROS), mitochondrial dysfunction, and initiation of apoptotic pathways [66]

Clin Genet 53(2):119125 Holme E, Kjellman B, Ronge E (1989) Betaine for treatment of homocystinuria caused by methylenetetrahydrofolate reductase deficiency

Targets 9 , 699713 (2005)

Finally, Pb 2+ trigger the inhibition of voltage-sensitive calcium channels (VSCCs) by blocking the L-type and other VSCCs, reducing Ca 2+ influx necessary for neurotransmitter release (e.g., glutamate) and synaptic plasticity [70,71]

That's in addition to, as mentioned by Gambit, excess alcohol causing issues with the liver which is the primary bodily store of B12

[DOI] [PMC free article] [PubMed] [Google Scholar] 82.Tharaux P.-L