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Lastly, significant human exposure via consumption of contaminated biota is not likely unless the plant or animal (terrestrial or aquatic) is from an area with 1,4-dioxane concentration levels that would result in sustained exposures

Autophagy deficiency promotes M1 macrophage polarization to exacerbate acute liver injury via ATG5 repression during aging

However, if methionine residue-35 of A were substituted by norleucine (TABLE 1) in which the S-atom of Met was replaced by a CH 2 -group, giving the molecule essentially the same side-chain length and dipole moment as the native peptide, no EPR spectrum was observed (109), even though any putative metal ions suggested by others would have been present

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The liver is the major metabolic clearing house for both endogenous chemicals (e.g., cholesterol, steroid hormones, fatty acids, and proteins) and xenobiotics