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explored various CD38/CD47 BsAbs, each with unique in vitro properties: IMM560526B4 displayed the most potent inhibitory effect on CD38 enzymatic activity, while IMM560512C10 was effective in directly killing MM cells and completely eradicating established tumors in mouse models (69)

Archived from the original on 10 May 2021

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MOTS-c modulates the FOXO transcription factors and regulates cellular senescence, the state in which aged or damaged cells stop dividing but refuse to die, instead secreting a cocktail of inflammatory signals known as the senescence-associated secretory phenotype (SASP)