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Description
Clin J Pain

A two-stage open-label Phase III study conducted by Besse B et al

The new tissue shows better organization and cross-linking, potentially creating stronger repairs than would occur naturally

Jan 2023

In particular, marked karyopyknosis of pyramidal cells of the hippocampus was observed, followed by moderate karyopyknosis and degeneration of Purkinje cells of the cerebellar cortex

Candidate regulatory mechanisms identified in plant models can subsequently be prioritized and validated in mammalian neuronal cell systems, thereby informing hypothesis generation for unresolved questions in neurodegenerative disease research
