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However, in some cases, PDAC was changed to a biologically more aggressive tumour after depletion of the stroma 14,15,16 , indicating that restoration of the fibrotic stromal homoeostasis maybe a more appealing therapeutic approach 17, 18

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Lancet 389:528537 Weinblatt ME, Coblyn JS, Fox DA, Fraser PA, Holdsworth DE, Glass DN, Trentham DE (1985) Efficacy of low-dose methotrexate in rheumatoid arthritis

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