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However, the duration of analgesia was longer for dermorphin than for [D-Arg]dermorphin when each was given at its maximally effective dose

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Creams are just, it's a passive diffusion

For some local diseases related to the skin or nervous system, such as skin nerve injury, local neuropathy, etc., cream formulations can directly deliver drugs to the affected area, increase the concentration of drugs locally, and enhance the therapeutic effect