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In sepsis-associated encephalopathy, NfL has demonstrated utility as a prognostic biomarker with elevated levels correlating with the degree of neuronal injury, encephalopathy severity, and worse long-term cognitive outcomes [87, 93,94,95]

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[DOI] [PubMed] [Google Scholar] 71

Within the mitochondria the first reaction of carnitine synthesis is catalyzed by the trimethyllysine hydroxylase, epison (also called trimethyllysine dioxygenase) enzyme encoded by the TMLHE gene