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Moreover, cancer cells carrying mutations of succinate dehydrogenase, fumarate hydrolase or isocitrate dehydrogenase accumulate -KG competitors including succinate, fumarate and 2-hydroxyglutarate, respectively 43,49,50

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[DOI] [PubMed] [Google Scholar] [75].Anderson ME, Meister A

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Werther GA, Hogg A, Oldfield BJ, McKinley MJ, Figdor R, Allen AM, et al

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The results significantly advanced the combination of relacorilant and nab-paclitaxel as a potential therapeutic strategy for treating patients with PROC

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