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[DOI] [PMC free article] [PubMed] [Google Scholar] 139.Singh B.N., Shankar S., Srivastava R.K

By inhibiting AKT1, luteolin activates the intrinsic apoptotic pathway, as evidenced by increased cleaved caspase-3, caspase-9, cytochrome c, and modulation of the Bax/Bcl-2 ratio (refer to Fig

The source data underlying Fig

In the same vein, OSI027 has been shown to induce apoptosis and autophagy in a battery of lymphoid tumoral cell lines and clinical samples, in a manner more effective than rapamycin (Gupta et al., 2012)

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