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The trial reported that epithalon increased midnight melatonin levels by 145% compared to pre-treatment serum melatonin

Protective effects of hericium erinaceus mycelium and its isolated erinacine A against Ischemia-Injury-Induced neuronal cell death via the Inhibition of iNOS/p38 MAPK and Nitrotyrosine

Eur J Microbiol Immunol (Bp)

A principal obstacle to successful CNS therapy is the highly selective BBB, which restricts the passage of nearly 98% low-MW compounds and effectively excludes most macromolecular agents from accessing the brain parenchyma (14)

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A randomized, placebo-controlled clinical trial showed that 500 mg of passionflower decreases anxiety before surgery.[ref] Another clinical trial also showed passionflower to be equal to oxazepam, a benzodiazepine, for generalized anxiety disorder.[ref] Kava Kava: Piper methysticum, or kava, is a traditional South Pacific medicinal plant that decreases anxiety by enhancing binding to GABA-A receptors and also blocking excitatory neurotransmitters