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There is a preferential transport of GSSG from the cytosol to the endoplasmic reticulum to maintain an adequate environment for protein disulfide bond formation and protein folding ( Glutathione and the -glutamyl cycle The synthesis, transport and catabolism of GSH occur in a series of enzymatic steps and transports of membrane that are collectively called -glutamyl cycle (Figure 5) ( - glutamyl cycle was postulated by Meister (Figure 5)

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764 The primary limitations in purified systems are the cost of enzyme preparation and the need to recycle cofactors and/or byproducts

Abstract Alpha-lipoic acid is an organic, sulfate-based compound produced by plants, humans, and animals

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