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Its substrate site-targeting mechanism inhibiting NNMT at the nicotinamide binding site provides selectivity over related methyltransferases and other enzymes in the NAD salvage pathway, making it a precise tool compound for studying NNMT-specific enzymatic activity in controlled laboratory systems
They convert to NAD+ through related but slightly different pathways
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Nevertheless, five high-grade tumors, according to histology, were classified as low-grade on cytology
