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In the acidic environment of the endosome, Fe 3+ is reduced to Fe 2+ by the six-transmembrane epithelial antigen of prostate 3 (Li et al., 2020

10.1002/mnfr.201500681 Mol Nutr Food Res

doi: 10.1007/s00018-018-2745-8 11 LuJHolmgrenA

These verdicts characterize the regulation of sortilin shedding and identify a novel mechanism by which sortilin ectodomain shedding acts as a regulatory switch for delivery of BDNF to the secretory pathway or to the lysosome, thus modulating the bioavailability of endogenous BDNF (Fig

2024), emphasizing the differential dose-dependent effect of and importance of regulation of these polyamines on behavioural and functional outcome

Severity of the underlying condition affects timeline expectations
