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Excessive iron levels can generate produce ROS via the Fenton reaction, activating various intracellular signaling pathways that enhance bone absorption and inhibit bone formation, thereby contributing to osteoporosis

10.1016/S0735-1097(99)00216-8 [DOI] [PubMed] [Google Scholar] 219.Scharfstein JS, Keaney JF, Jr., Slivka A, Welch GN, Vita JA, Stamler JS, et al

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The process of necrosis activates macrophages and dendritic cells and enhances their capacity to produce nitric oxide and interferon alpha in SLE

In accordance with phenomena described above, simultaneous inactivation of phosphatase and tensin homolog (PTEN