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Functional studies indicate that glutathione peroxidase activity saturates at 7090 g/L serum selenium, further explaining why supplementation beyond this threshold may not enhance antioxidant capacity ( 5.4 Practical considerations In selenium-replete populations, large trials (e.g., SELECT) found no reduction in cardiovascular events with 200 g/day of selenomethionine and even observed a potential rise in type 2 diabetes incidence (Zhang et al., 2017)

Psychostimulants, such as methamphetamine, cocaine and synthetic cathinones, disrupt monoaminergic neurotransmission, causing cognitive impairment, psychiatric disturbances, and neurovascular damage

This neurotoxin triggers the death signaling pathway by activating apoptosis signal regulating kinase 1 (ASK1) and translocating the death domain associated protein (DAXX) in the substantia nigra pars compacta (SNpc) of mice

S., Nishi, H

Michaelidou K, Agelaki S, Mavridis K