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Ferroptosis, a cell death pathway distinct from apoptosis and necrosis, was described in fibrosarcoma cells exposed to erastin

AX is a non-enzymatic and potent antioxidant that prevents chain reactions by bursting unilinear oxygen species and scavenging free radicals (Brotosudarmo et al., 2020), reducing the production of hemolymph ROS by Chinese mitten crabs ( Eriocheir sinensis ) under high pH stress (Wang et al., 2018a), inhibiting excessive hemocyte ROS production induced by high temperature stress in pufferfish ( Takifugu obscurus ) (Cheng et al., 2018), and alleviating the oxidative stress damage induced by oxidized fish-oil diet in Litopenaeus vannamei (Yu et al., 2020)

Finally, apremilast also decreases the systemic inflammatory status of patients with psoriasis, decreasing TNF-, IFN-, IL-12, and IL-23 production (17)

10.1046/j.1365-313X.2003.01656.x 41 GallieD

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

(PubMed) Gritz DC, Srinivasan M, Smith SD, et al