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Expression profiling reveals off-target gene regulation by RNAi

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[DOI] [PMC free article] [PubMed] [Google Scholar] 45.Wen, F

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A detailed analysis of the antiobesity action of fenfluramine disclosed that it directly activates hypothalamic POMC neurons through 5-hydroxytryptamine 2C (5-HT2C) receptors that are expressed on a majority of these cells [80]
