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Once established and validated, these schemes can then be applied to analyze the metabolite patterns of unknown compounds and based on this to predict their potential toxicity

JAMA 291 : 187-194

Dystonia: a disorder often misdiagnosed as a conversion reaction

Previous studies have reported that PKM2 is enzymatically active toward pyruvate only as a tetramer and acts as a transcription factor coactivator when tetrameric PKM2 dissociates into a dimer 28,29

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This global coverage makes it particularly well suited for exploratory studies, such as comparative proteome analysis, pathway discovery, and early-stage biomarker identification, where the relevant proteins and biological drivers are not yet known