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[DOI] [PMC free article] [PubMed] [Google Scholar] 125.Piacentini S., Polimanti R., Iorio A., et al

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Due to the negative feedback by IGF-1 on the hypothalamus, growth hormone (GH) levels decrease significantly

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Saari (98) demonstrated that dietary copper deficiency resulted in various cardiovascular defects with systemic effects including hypertension, increased inflammation, anaemia decreased blood clotting and possibly atherosclerosis, which also has effects on specific organs or tissues such as diminished structural integrity of the heart and blood vessels, impaired energy use by the heart, decreased contractility of the heart, altered ability for blood vessels to control their diameter growth and structural-functional changes in circulating blood cells