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Chronic Inflammatory Bowel Disease (IBD) Inflammation of the ileum and disruption of the gut barrier can significantly reduce B12 absorption

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

doi: 10.1056/NEJMoa1003114

However, no controlled human trial has compared oral versus injectable AOD-9604 at equivalent systemic doses

Finally, a gastric bypass can lead to a deficiency when it disrupts the production of intrinsic factor in the stomach

In any case, its clear that supplementing with B12 is probably not the best solution for improving hair growth at least as a standalone therapy