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Savage MO, Camacho-Hbner C, Dunger DB

Rats received AOD 9604 daily for 6 months and cynomolgus monkeys for 9 months

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Apply a small amount to a discrete area, wait 24 to 48 hours, and check for reaction before proceeding with scalp application

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This suggests that AOD 9604 may potentially augment the anti-cancer potency of doxorubicin while possibly minimizing unintended actions associated with non-target tissue exposure